Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polyunsaturated fatty acid 5-lipoxygenase | ||
| Ligand | BDBM50085173 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_86312 (CHEMBL696464) | ||
| IC50 | 20±n/a nM | ||
| Citation |  Kolasa, T; Gunn, DE; Bhatia, P; Woods, KW; Gane, T; Stewart, AO; Bouska, JB; Harris, RR; Hulkower, KI; Malo, PE; Bell, RL; Carter, GW; Brooks, CD Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors. J Med Chem43:690-705 (2000) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polyunsaturated fatty acid 5-lipoxygenase | |||
| Name: | Polyunsaturated fatty acid 5-lipoxygenase | ||
| Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 77972.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay. | ||
| Residue: | 674 | ||
| Sequence: |
| ||
| BDBM50085173 | |||
| n/a | |||
| Name | BDBM50085173 | ||
| Synonyms: | 2-{Adamantan-2-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methoxyimino}-propionic acid | CHEMBL348939 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H32N2O4 | ||
| Mol. Mass. | 484.5861 | ||
| SMILES | C\C(=N/OC(C1C2CC3CC(C2)CC1C3)c1ccc(OCc2ccc3ccccc3n2)cc1)C(O)=O |TLB:4:5:12:8.14.9,7:8:12:5.6.11,THB:9:8:5:10.12.11,9:10:5:8.7.14,7:6:12:8.14.9,(19.63,-4.14,;19.63,-5.68,;18.3,-6.45,;16.96,-5.68,;15.64,-6.45,;15.63,-7.99,;14.46,-8.89,;12.72,-8.74,;13.97,-9.66,;14.39,-11.12,;16.01,-11.14,;14.87,-10.25,;17.24,-10.21,;16.82,-8.74,;15.22,-8.67,;14.32,-5.68,;14.32,-4.14,;12.97,-3.37,;11.65,-4.14,;10.33,-3.37,;9.01,-4.15,;7.68,-3.37,;7.66,-1.82,;6.33,-1.07,;4.99,-1.84,;3.66,-1.07,;2.33,-1.84,;2.33,-3.39,;3.66,-4.16,;4.99,-3.37,;6.33,-4.15,;11.65,-5.66,;12.97,-6.43,;20.94,-6.45,;20.97,-7.96,;22.29,-5.68,)| | ||
| Structure | 
| ||