Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50105085 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_145324 (CHEMBL750412) |
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IC50 | 353±n/a nM |
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Citation | Poulain, R; Horvath, D; Bonnet, B; Eckhoff, C; Chapelain, B; Bodinier, MC; Déprez, B From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. J Med Chem44:3378-90 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50105085 |
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n/a |
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Name | BDBM50105085 |
Synonyms: | 17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alpha,14-triol | CHEMBL895 | N-cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol | NALBUPHINE | US10231963, Table B.1 | US10512644, Compound Nalbuphine | US11534436, Compound Table B.1 | US9233167, Nalbuphine | US9656961, Example 00118 | USRE49340, Rank 9 |
Type | Small organic molecule |
Emp. Form. | C21H27NO4 |
Mol. Mass. | 357.4434 |
SMILES | O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CCC1)c45 |r| |
Structure |
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