Ki Summary

Reaction Details

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Target

Genome polyprotein

Ligand

BDBM50112582

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_158769 (CHEMBL772930)

8800±n/a nM

Citation

St Hilaire, PM; Alves, LC; Herrera, F; Renil, M; Sanderson, SJ; Mottram, JC; Coombs, GH; Juliano, MA; Juliano, L; Arevalo, J; Meldal, M Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. J Med Chem45:1971-82 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Genome polyprotein

Name:

Genome polyprotein

Synonyms:

Human rhinovirus A protease | Human rhinovirus B 3A protease

Type:

PROTEIN

Mol. Mass.:

44361.04

Organism:

Human rhinovirus B

Description:

ChEMBL_158953

Residue:

401

Sequence:

AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMS
AIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIA
NIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVIT
TGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDR
NEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYN
YPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQT
IHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA

BDBM50112582

n/a

Name

BDBM50112582

Synonyms:

6-Amino-2-[2-(2-{2-[2-(2-{6-amino-2-[(pyrrolidine-2-carbonyl)-amino]-hexanoylamino}-3-phenyl-propionylamino)-5-guanidino-pentylamino]-3-hydroxy-propionylamino}-3-phenyl-propionylamino)-3-carbamoyl-propionylamino]-hexanoic acid | CHEMBL386926

Type

Small organic molecule

Emp. Form.

C48H76N14O10

Mol. Mass.

1009.2048

SMILES

NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1CCCN1)C(O)=O

Structure