| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Ligand | BDBM50067843 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_70737 (CHEMBL681127) |
|---|
| IC50 | 190±n/a nM |
|---|
| Citation |  Pedretti, A; Villa, L; Vistoli, G Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem45:1460-5 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Synonyms: | Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit | Protein farnesyltransferase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 69815 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | CAAX farnesyltransferase subunit beta | FNTB_RAT | FTase-beta | Fntb | Protein farnesyltransferase | Protein farnesyltransferase subunit beta | Ras proteins prenyltransferase subunit beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48666.41 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | EBI_10573 |
|---|
| Residue: | 437 |
|---|
| Sequence: | MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPV
PGFEECEDAVTSDPATD
|
|
|
|---|
| Component 2 |
| Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Synonyms: | CAAX farnesyltransferase alpha subunit | FNTA_RAT | FTase-alpha | Fnta | GGTase-I-alpha | Protein farnesyltransferase | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Ras proteins prenyltransferase alpha | Type I protein geranyl-geranyltransferase alpha subunit | geranylgeranyltransferase type-I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44030.14 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Recombinant rat enzyme. |
|---|
| Residue: | 377 |
|---|
| Sequence: | MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDS
PTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLK
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQR
HFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSRESDIPASV
|
|
|
|---|
| BDBM50067843 |
|---|
| n/a |
|---|
| Name | BDBM50067843 |
|---|
| Synonyms: | (S)-2-[(3aR,6R)-3-(1,5-Dimethyl-hexyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-ylmethyl]-succinic acid | 2-[3-(1,5-Dimethyl-hexyl)-3a,6-dimethyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-ylmethyl]-succinic acid(Des-B) | CHEMBL35674 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H46O5 |
|---|
| Mol. Mass. | 462.6618 |
|---|
| SMILES | CC(C)CCCC(C)C1CCC2C3CCC(=O)[C@](C)(C[C@@H](CC(O)=O)C(O)=O)C3CC[C@]12C |
|---|
| Structure | 
|
|---|
Search and Browse
