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TargetCarbonic anhydrase 2
LigandBDBM50292127
Substrate/Competitorn/a
Meas. Tech.ChEMBL_45044 (CHEMBL658042)
Ki 1±n/a nM
Citation Scozzafava, AMenabuoni, LMincione, FSupuran, CT Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties. J Med Chem45:1466-76 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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  Blast E-value cutoff:
BDBM50292127
n/a
NameBDBM50292127
Synonyms:CHEMBL262651 | {{2-[Carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-2,5-dihydro-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-sulfamoyl-2,5-dihydro-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid
TypeSmall organic molecule
Emp. Form.C18H31N11O12S4
Mol. Mass.721.765
SMILESNS(=O)(=O)C1=NNC(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)NC2NN=C(S2)S(N)(=O)=O)CC(O)=O)CC(O)=O)S1 |c:29,t:4|
Structure
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