| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 2 |
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| Ligand | BDBM50162490 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305824 (CHEMBL829566) |
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| IC50 | 1.14±n/a nM |
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| Citation |  Cappellacci, L; Franchetti, P; Pasqualini, M; Petrelli, R; Vita, P; Lavecchia, A; Novellino, E; Costa, B; Martini, C; Klotz, KN; Grifantini, M Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J Med Chem48:1550-62 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 2 |
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| Name: | Adenylate cyclase type 2 |
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| Synonyms: | ADCY2_RAT | ATP pyrophosphate-lyase 2 | Adcy2 | Adenylate cyclase | Adenylate cyclase type 2 | Adenylate cyclase type II | Adenylyl cyclase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123344.82 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_305824 |
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| Residue: | 1090 |
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| Sequence: | MRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGACLAL
LAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWICLVAMG
YLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSVYLSATP
GAKEHLFWQILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQE
RLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTR
LASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKM
GLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGV
PGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRH
TLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLR
TKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKNIEKEYRATALPAFK
YYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASTS
LMWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSV
PDNQASILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTH
AHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKE
REEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYT
ESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQ
EPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIW
GNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMS
RSLSQSNLAS
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| BDBM50162490 |
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| n/a |
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| Name | BDBM50162490 |
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| Synonyms: | 5-(6-Cyclohexylamino-purin-9-yl)-tetrahydro-furan-2,3,4-triol | CHEMBL193521 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H21N5O4 |
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| Mol. Mass. | 335.3583 |
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| SMILES | O[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCCC3)ncnc12 |
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| Structure | 
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