| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50144948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303550 (CHEMBL828801) |
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| Ki | 1120±n/a nM |
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| Citation |  Cappellacci, L; Franchetti, P; Pasqualini, M; Petrelli, R; Vita, P; Lavecchia, A; Novellino, E; Costa, B; Martini, C; Klotz, KN; Grifantini, M Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J Med Chem48:1550-62 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36602.99 |
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| Organism: | BOVINE |
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| Description: | ADENOSINE 0 BOVINE::P28190 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
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| BDBM50144948 |
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| n/a |
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| Name | BDBM50144948 |
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| Synonyms: | (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol | (2R,3R,4R,5R)-5-Hydroxymethyl-3-methyl-2-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol | 2'-C-methyladenosine | 2'-methyl-adenosine | 2-C-methyl adenosine | CHEMBL73809 | beta-2'-Methyladenosine |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15N5O4 |
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| Mol. Mass. | 281.2679 |
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| SMILES | C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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