Reaction Details |
| Report a problem with these data |
Target | DNA polymerase III PolC-type |
---|
Ligand | BDBM21686 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_334242 (CHEMBL861887) |
---|
Ki | 66±n/a nM |
---|
Citation | Zhi, C; Long, ZY; Manikowski, A; Comstock, J; Xu, WC; Brown, NC; Tarantino, PM; Holm, KA; Dix, EJ; Wright, GE; Barnes, MH; Butler, MM; Foster, KA; LaMarr, WA; Bachand, B; Bethell, R; Cadilhac, C; Charron, S; Lamothe, S; Motorina, I; Storer, R Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. J Med Chem49:1455-65 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA polymerase III PolC-type |
---|
Name: | DNA polymerase III PolC-type |
Synonyms: | DNA polymerase III | DNA polymerase IIIC | DNA-directed DNA polymerase | DPO3_BACSU | PolIII | dnaF | mutI | polC |
Type: | Enzyme |
Mol. Mass.: | 162625.67 |
Organism: | Bacillus subtilis |
Description: | Enzyme was purified from recombinant strains. |
Residue: | 1437 |
Sequence: | MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASKSWHFHFQFKSLLPFQI
YDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCIEELQGISPPIISLLNQQK
PKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPDLQLDAEIFVSEQEVQKFREQ
KLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQIKDNEEIRTLDSIMDEERRITV
QGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFAREKEDAALMKSLKKGMWVKARGSI
QNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKRVELHLHSPMSQMDAVTGIGKLVEQAK
KWGHEAIALTDHAVVQSFPDAYSAAKKHGIKMIYGMEANLVDDGVPIAYNAAHRLLEEET
YVVFDVETTGLSAVYDTIIELAAVKVKGGEIIDKFEAFANPHRPLSATIIELTGITDDML
QDAPDVVDVIRDFREWIGDDILVAHNASFDMGFLNVAYKKLLEVEKAKNPVIDTLELGRF
LYPEFKNHRLNTLCKKFDIELTQHHRAIYDTEATAYLLLKMLKDAAEKGIQYHDELNENM
GQSNAYQRSRPYHATLLAVNSTGLKNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIG
SACDRGEVFEGMMQKSPEEVEDIASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANI
TKLGEKLNKPVVATGNVHYLNDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEA
FSFLGEEKAKEIVVTNTQKVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGE
ELPEIVEARIEKELKSIIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEI
TEVNPLPPHYVCPECQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFK
GDKVPDIDLNFSGEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLH
MRGAEIDRLVQGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDF
HSIHDNLLKLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIG
CKTGTLGIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELS
EVIGCRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKI
KYMFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED
INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNSIP
GLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSLF
|
|
|
BDBM21686 |
---|
n/a |
---|
Name | BDBM21686 |
Synonyms: | 3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)uracil | 6-[(3-ethyl-4-methylphenyl)amino]-3-(4-hydroxybutyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | CHEMBL327687 | HB-EMAU | HBEMAU |
Type | Small organic molecule |
Emp. Form. | C17H23N3O3 |
Mol. Mass. | 317.3828 |
SMILES | CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C |
Structure |
|