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TargetDNA polymerase III PolC-type
LigandBDBM50182672
Substrate/Competitorn/a
Meas. Tech.ChEMBL_334242 (CHEMBL861887)
Ki 18±n/a nM
Citation Zhi, CLong, ZYManikowski, AComstock, JXu, WCBrown, NCTarantino, PMHolm, KADix, EJWright, GEBarnes, MHButler, MMFoster, KALaMarr, WABachand, BBethell, RCadilhac, CCharron, SLamothe, SMotorina, IStorer, R Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. J Med Chem49:1455-65 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase III PolC-type
Name:DNA polymerase III PolC-type
Synonyms:DNA polymerase III | DNA polymerase IIIC | DNA-directed DNA polymerase | DPO3_BACSU | PolIII | dnaF | mutI | polC
Type:Enzyme
Mol. Mass.:162625.67
Organism:Bacillus subtilis
Description:Enzyme was purified from recombinant strains.
Residue:1437
Sequence:
MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASKSWHFHFQFKSLLPFQI
YDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCIEELQGISPPIISLLNQQK
PKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPDLQLDAEIFVSEQEVQKFREQ
KLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQIKDNEEIRTLDSIMDEERRITV
QGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFAREKEDAALMKSLKKGMWVKARGSI
QNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKRVELHLHSPMSQMDAVTGIGKLVEQAK
KWGHEAIALTDHAVVQSFPDAYSAAKKHGIKMIYGMEANLVDDGVPIAYNAAHRLLEEET
YVVFDVETTGLSAVYDTIIELAAVKVKGGEIIDKFEAFANPHRPLSATIIELTGITDDML
QDAPDVVDVIRDFREWIGDDILVAHNASFDMGFLNVAYKKLLEVEKAKNPVIDTLELGRF
LYPEFKNHRLNTLCKKFDIELTQHHRAIYDTEATAYLLLKMLKDAAEKGIQYHDELNENM
GQSNAYQRSRPYHATLLAVNSTGLKNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIG
SACDRGEVFEGMMQKSPEEVEDIASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANI
TKLGEKLNKPVVATGNVHYLNDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEA
FSFLGEEKAKEIVVTNTQKVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGE
ELPEIVEARIEKELKSIIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEI
TEVNPLPPHYVCPECQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFK
GDKVPDIDLNFSGEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLH
MRGAEIDRLVQGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDF
HSIHDNLLKLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIG
CKTGTLGIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELS
EVIGCRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKI
KYMFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED
INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNSIP
GLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50182672
n/a
NameBDBM50182672
Synonyms:1-ethyl-7-(4-(4-(4-(3-ethyl-4-methylphenylamino)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)butyl)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | CHEMBL383544
TypeSmall organic molecule
Emp. Form.C32H38FN7O5
Mol. Mass.619.6864
SMILESCCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3)c3nc4n(CC)cc(C(O)=O)c(=O)c4cc3F)c(=O)[nH]2)ccc1C
Structure
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