Reaction Details |
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Target | Progesterone receptor |
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Ligand | BDBM50206106 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_442524 (CHEMBL892689) |
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IC50 | 0.27±n/a nM |
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Citation | Kang, FA; Guan, J; Jain, N; Allan, G; Linton, O; Tannenbaum, P; Chen, X; Xu, J; Zhu, P; Gunnet, J; Demarest, K; Lundeen, S; Sui, Z Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists. Bioorg Med Chem Lett17:2531-4 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Progesterone receptor |
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Name: | Progesterone receptor |
Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
Type: | Protein |
Mol. Mass.: | 98979.52 |
Organism: | Homo sapiens (Human) |
Description: | P06401 |
Residue: | 933 |
Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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BDBM50206106 |
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n/a |
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Name | BDBM50206106 |
Synonyms: | (8S,11R,13S,14R)-11-(4-dimethylamino-phenyl)-17-(4-fluoro-phenylethynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one | (8S,11R,13S,14R,17S)-11-(4-Dimethylamino-phenyl)-17-(4-fluoro-phenylethynyl)-17-hydroxy-13-methyl-1,2,8,11,12,13,14,15,16,17-decahydro-6H-7-oxa-cyclopenta[a]phenanthren-3-one | CHEMBL232219 |
Type | Small organic molecule |
Emp. Form. | C33H34FNO3 |
Mol. Mass. | 511.6264 |
SMILES | CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#Cc2ccc(F)cc2)[C@@H]2OCC3=CC(=O)CCC3=C12 |r,t:33,40| |
Structure |
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