Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Sodium-dependent serotonin transporter |
---|
Ligand | BDBM50173717 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_457377 (CHEMBL940969) |
---|
IC50 | 4.1±n/a nM |
---|
Citation | Dalton King, H; Denhart, DJ; Deskus, JA; Ditta, JL; Epperson, JR; Higgins, MA; Kung, JE; Marcin, LR; Sloan, CP; Mattson, GK; Molski, TF; Krause, RG; Bertekap, RL; Lodge, NJ; Mattson, RJ; Macor, JE Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor. Bioorg Med Chem Lett17:5647-51 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent serotonin transporter |
---|
Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
BDBM50173717 |
---|
n/a |
---|
Name | BDBM50173717 |
Synonyms: | ((1S,2S)-2-(5-fluoro-1H-indol-3-yl)cyclopropyl)-N,N-dimethylmethanamine | (+)[(1S,2S)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropylmethyl]-dimethyl-amine | CHEMBL198019 | [(1S,2S)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropylmethyl]-dimethyl-amine |
Type | Small organic molecule |
Emp. Form. | C14H17FN2 |
Mol. Mass. | 232.2966 |
SMILES | CN(C)C[C@H]1C[C@@H]1c1c[nH]c2ccc(F)cc12 |
Structure |
|