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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neutrophil elastase | ||
| Ligand | BDBM50211722 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_459044 (CHEMBL925136) | ||
| Ki | 410±n/a nM | ||
| Citation |  Brauer, AB; McBride, JD; Kelly, G; Matthews, SJ; Leatherbarrow, RJ Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds. Bioorg Med Chem15:4618-28 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neutrophil elastase | |||
| Name: | Neutrophil elastase | ||
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 28532.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08246 | ||
| Residue: | 267 | ||
| Sequence: |
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| BDBM50211722 | |||
| n/a | |||
| Name | BDBM50211722 | ||
| Synonyms: | (2S)-2-{[(3S,9S,12S,15S,18S,21R,26R,29S,32S)-21-[(2S)-2-aminohexanamido]-9-[(2S)-butan-2-yl]-29-(2-carbamoylethyl)-15,18-bis[(1R)-1-hydroxyethyl]-12-(hydroxymethyl)-2,8,11,14,17,20,28,31-octaoxo-23,24-dithia-1,7,10,13,16,19,27,30-octaazatricyclo[30.3.0.0^{3,7}]pentatriacontan-26-yl]amino}-3-(4-hydroxyphenyl)propanoic acid | CHEMBL401765 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C52H82N12O16S2 | ||
| Mol. Mass. | 1195.408 | ||
| SMILES | CCCC[C@H](N)C(=O)N[C@H]1CSSC[C@H](N[C@@H](Cc2ccc(O)cc2)C(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC | ||
| Structure | 
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