Ki Summary

Reaction Details

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Target

Peroxisome proliferator-activated receptor delta

Ligand

BDBM50225835

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_468714 (CHEMBL929850)

EC50

>100000±n/a nM

Citation

Asaki, T; Aoki, T; Hamamoto, T; Sugiyama, Y; Ohmachi, S; Kuwabara, K; Murakami, K; Todo, M Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. Bioorg Med Chem16:981-94 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peroxisome proliferator-activated receptor delta

Name:

Peroxisome proliferator-activated receptor delta

Synonyms:

Type:

Enzyme

Mol. Mass.:

49910.45

Organism:

Homo sapiens (Human)

Description:

Q03181

Residue:

441

Sequence:

MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY

BDBM50225835

n/a

Name

BDBM50225835

Synonyms:

(2s,5s)-2-methyl-5-(4-(5-methyl-2-p-tolyloxazol-4-yl)butyl)-1,3-dioxane-2-carboxylic acid | 2-methyl-c-5-{4-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]butyl}-1,3-dioxane-r-2-carboxylicacid | CHEMBL270960 | cis-2-methyl-5-(4-(5-methyl-2-p-tolyloxazol-4-yl)butyl)-1,3-dioxane-2-carboxylic acid

Type

Small organic molecule

Emp. Form.

C21H27NO5

Mol. Mass.

373.4428

SMILES

Cc1oc(nc1CCCC[C@H]1CO[C@](C)(OC1)C(O)=O)-c1ccc(C)cc1 |r,wU:10.10,13.18,wD:13.14,(.84,-5.21,;-.3,-6.25,;-1.81,-5.93,;-2.58,-7.27,;-1.54,-8.41,;-.13,-7.78,;1.21,-8.54,;2.54,-7.78,;3.88,-8.54,;5.21,-7.77,;6.55,-8.54,;7.87,-7.77,;9.2,-8.55,;9.2,-10.09,;10.74,-10.08,;7.87,-10.85,;6.54,-10.08,;9.19,-11.62,;10.52,-12.4,;7.86,-12.38,;-4.11,-7.44,;-5.01,-6.19,;-6.54,-6.36,;-7.17,-7.77,;-8.7,-7.93,;-6.25,-9.01,;-4.72,-8.84,)|

Structure