| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50374523 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_469497 (CHEMBL931979) |
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| IC50 | 4.6±n/a nM |
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| Citation |  Pasternak, A; Goble, SD; Doss, GA; Tsou, NN; Butora, G; Vicario, PP; Ayala, JM; Struthers, M; Demartino, JA; Mills, SG; Yang, L Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists. Bioorg Med Chem Lett18:1374-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50374523 |
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| n/a |
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| Name | BDBM50374523 |
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| Synonyms: | CHEMBL402532 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33F4NO2 |
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| Mol. Mass. | 515.5821 |
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| SMILES | C[C@H]1CN(CC[C@@]11C=Cc2ccccc12)[C@@H]1CC[C@@]2(CCO[C@H]2OCc2cc(F)cc(c2)C(F)(F)F)C1 |c:8| |
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| Structure | 
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