| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 1 |
|---|
| Ligand | BDBM50375544 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_472923 (CHEMBL921166) |
|---|
| IC50 | 5190±n/a nM |
|---|
| Citation |  Schäfer, S; Saunders, L; Eliseeva, E; Velena, A; Jung, M; Schwienhorst, A; Strasser, A; Dickmanns, A; Ficner, R; Schlimme, S; Sippl, W; Verdin, E; Jung, M Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem16:2011-33 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 1 |
|---|
| Name: | Histone deacetylase 1 |
|---|
| Synonyms: | HDAC1_RAT | Hdac1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55080.30 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_472921 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEF
SDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
MA
|
|
|
|---|
| BDBM50375544 |
|---|
| n/a |
|---|
| Name | BDBM50375544 |
|---|
| Synonyms: | CHEMBL263884 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H34N2O5 |
|---|
| Mol. Mass. | 490.5907 |
|---|
| SMILES | COC(=O)[C@H](Cc1ccc(cc1)-c1ccc2ccccc2c1)NC(=O)CCCCCCCC(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
