| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 2 |
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| Ligand | BDBM50031704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_487957 (CHEMBL1013088) |
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| Ki | 17.0±n/a nM |
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| Citation |  Sagot, E; Pickering, DS; Pu, X; Umberti, M; Stensbøl, TB; Nielsen, B; Chapelet, M; Bolte, J; Gefflaut, T; Bunch, L Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. J Med Chem51:4093-103 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 2 |
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| Name: | Glutamate receptor ionotropic, kainate 2 |
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| Synonyms: | GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102478.61 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_936439 |
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| Residue: | 908 |
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| Sequence: | MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
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| BDBM50031704 |
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| n/a |
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| Name | BDBM50031704 |
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| Synonyms: | (2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4R)-2-amino-4-methylpentanedioic acid | (2S,4R)-4-methylglutamic acid | 2-Amino-4-methyl-pentanedioic acid | CHEMBL288166 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H11NO4 |
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| Mol. Mass. | 161.1558 |
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| SMILES | C[C@H](C[C@H](N)C(O)=O)C(O)=O |r| |
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| Structure | 
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