| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, NMDA 1 |
|---|
| Ligand | BDBM50252889 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_539074 (CHEMBL1036605) |
|---|
| IC50 | 68±n/a nM |
|---|
| Citation |  Tahirovic, YA; Geballe, M; Gruszecka-Kowalik, E; Myers, SJ; Lyuboslavsky, P; Le, P; French, A; Irier, H; Choi, WB; Easterling, K; Yuan, H; Wilson, LJ; Kotloski, R; McNamara, JO; Dingledine, R; Liotta, DC; Traynelis, SF; Snyder, JP Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. J Med Chem51:5506-21 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor ionotropic, NMDA 1 |
|---|
| Name: | Glutamate receptor ionotropic, NMDA 1 |
|---|
| Synonyms: | Glutamate (NMDA) receptor subunit zeta 1 | Glutamate [NMDA] receptor subunit zeta-1 | Glutamate-NMDA-Channel | Glutamate-NMDA-MK801 | Glutamate-NMDA-Polyamine | Grin1 | NMDA | NMDZ1_RAT | Nmdar1 | phencyclidine |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 105533.40 |
|---|
| Organism: | RAT |
|---|
| Description: | P35439 |
|---|
| Residue: | 938 |
|---|
| Sequence: | MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRL
ETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNM
TGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTC
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
|
|
|
|---|
| BDBM50252889 |
|---|
| n/a |
|---|
| Name | BDBM50252889 |
|---|
| Synonyms: | (S)-1-(4-Methanesulfonamidophenoxy)-3-(3-fluoro-4-chorophenylethylamino)-2-propanol | CHEMBL493053 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22ClFN2O4S |
|---|
| Mol. Mass. | 416.895 |
|---|
| SMILES | CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(F)c2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
