Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50304090 (CHEMBL594615 | N-(4-(3-(2-(3,4-Dichlorophenylamino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2A (Rattus norvegicus (Rat)) | BDBM213889 (5,7-Dichlorokynurenic acid (5,7-DCKA)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 65 | -41.0 | 92 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50304085 (CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 119 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membrane | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2D (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | >300 | >-37.2 | >3.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50304088 (CHEMBL596046 | N-(4-(2-(2-(3,4-Dichlorophenylamino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50304087 (CHEMBL596036 | N-(4-(2-(3-(3,4-Dichlorophenyl)-2-o...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membrane | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168618 (US9079852, Table F, Compound 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 553 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2A (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | 560 | -35.7 | 770 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | >800 | >-34.8 | >3.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50304086 (CHEMBL594417 | N-(4-(2-(4-(3,4-Dichlorophenyl)pipe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 817 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membrane | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168620 (US9079852, Table F, Compound 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | >1.30E+3 | >-33.6 | >3.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168617 (US9079852, Table F, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50304091 (CHEMBL609857 | N-(3,4-Dichlorocinnamyl)-3-(4-(meth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50304089 (CHEMBL595318 | N-(2-(3,4-Dichlorophenylamino)ethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cells | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168626 (US9079852, Table F, Compound 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168625 (US9079852, Table F, Compound 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168622 (US9079852, Table F, Compound 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168621 (US9079852, Table F, Compound 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H2 receptor (Homo sapiens (Human)) | BDBM50440057 (CHEMBL2426097) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of histamine H2 receptor (unknown origin) | J Med Chem 56: 6434-56 (2013) Article DOI: 10.1021/jm400652r BindingDB Entry DOI: 10.7270/Q26H4JTJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168624 (US9079852, Table F, Compound 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168619 (US9079852, Table F, Compound 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 [F484A,T518L]/3A (Rattus norvegicus (Rat)) | BDBM213889 (5,7-Dichlorokynurenic acid (5,7-DCKA)) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 3.50E+4 | -25.4 | 9.70E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM168616 (US9079852, Table F, Compound 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 [F484A,T518L]/3B (Rattus norvegicus (Rat)) | BDBM213889 (5,7-Dichlorokynurenic acid (5,7-DCKA)) | PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | >1.50E+5 | >-21.8 | >3.00E+5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor 1 (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | >1.80E+5 | >-21.4 | >3.00E+5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2C (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253203 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-bromob...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50252672 ((S)-1-(4-Methanesulfonamidephenoxy)-3-(3,4-dichlor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253241 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2,3,4-tr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1/2B (Rattus norvegicus (Rat)-RAT) | BDBM50304085 (CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Antagonist activity at rat recombinant NR1/NR2B receptor expressed in frog oocytes assessed as inhibition of glutamate/glycine-induced current by two... | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1/2B (Rattus norvegicus (Rat)-RAT) | BDBM50304085 (CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Antagonist activity at wild type rat NR1/NR2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced curren... | Bioorg Med Chem 17: 6463-80 (2009) Article DOI: 10.1016/j.bmc.2009.05.085 BindingDB Entry DOI: 10.7270/Q2M61KB5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50252889 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(3-fluoro-4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50253032 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-butyl-3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human ERG expressed in HEK293 cells | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50252673 ((S)-1-(4-Methanesulfonamido-2-fluorophenoxy)-3-(3,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50007674 ((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253204 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-fluoro...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253003 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-ethyl-3,4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM168626 (US9079852, Table F, Compound 11) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM168624 (US9079852, Table F, Compound 9) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50252886 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(4-chlorophe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253078 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(4-hydrox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253030 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-hydrox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50253031 ((S)-1-(4-Methanesulfonamidophenoxy)3-(N-propyl-3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human ERG expressed in HEK293 cells | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253002 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50253120 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2,4-dihy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b... | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM168625 (US9079852, Table F, Compound 10) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University; NeurOp, Inc. US Patent | Assay Description Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ... | US Patent US9079852 (2015) BindingDB Entry DOI: 10.7270/Q2K35SF5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2D (Rattus norvegicus (Rat)) | BDBM213888 (1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of Copenhagen | Assay Description Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl... | J Biol Chem 288: 33124-35 (2013) Article DOI: 10.1074/jbc.M113.480210 BindingDB Entry DOI: 10.7270/Q2MG7NB1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50253003 ((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-ethyl-3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]astemizole from human ERG expressed in HEK293 cells | J Med Chem 51: 5506-21 (2008) Article DOI: 10.1021/jm8002153 BindingDB Entry DOI: 10.7270/Q2PZ59QH | |||||||||||
More data for this Ligand-Target Pair |
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