| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
|---|
| Ligand | BDBM50276520 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_541733 (CHEMBL1023095) |
|---|
| IC50 | 2.6±n/a nM |
|---|
| Citation |  Havale, SH; Pal, M Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem17:1783-802 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 4 |
|---|
| Name: | Dipeptidyl peptidase 4 |
|---|
| Synonyms: | Cd26 | DPP4_MOUSE | Dipeptidyl peptidase IV | Dpp4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 87433.73 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1335112 |
|---|
| Residue: | 760 |
|---|
| Sequence: | MKTPWKVLLGLLGVAALVTIITVPIVLLSKDEAAADSRRTYSLADYLKSTFRVKSYSLWW
VSDFEYLYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVSPDRLFVLLEYNYVKQWRH
SYTASYNIYDVNKRQLITEEKIPNNTQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHRIT
STGEENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESL
QYPKTVWIPYPKAGAVNPTVKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVVWA
TEERISLQWLRRIQNYSVMAICDYDKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTS
DGSSFYKIISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEALTSDYLYYISNQYKEMP
GGRNLYKIQLTDHTNVKCLSCDLNPERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHRST
DHKELRVLEDNSALDRMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLLDV
YAGPCSQKADASFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQ
IEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVY
TERYMGLPIPEDNLDHYRNSTVMSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDA
GVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLH
|
|
|
|---|
| BDBM50276520 |
|---|
| n/a |
|---|
| Name | BDBM50276520 |
|---|
| Synonyms: | (2R,4R)-4-fluoro-1-(2-(4-methyl-1-(methylsulfonyl)piperidin-4-ylamino)acetyl)pyrrolidine-2-carbonitrile | CHEMBL456419 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H23FN4O3S |
|---|
| Mol. Mass. | 346.421 |
|---|
| SMILES | CC1(CCN(CC1)S(C)(=O)=O)NCC(=O)N1C[C@H](F)C[C@@H]1C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
