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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 | ||
| Ligand | BDBM50137251 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_541717 (CHEMBL1021164) | ||
| IC50 | 88±n/a nM | ||
| Citation |  Havale, SH; Pal, M Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem17:1783-802 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 | |||
| Name: | Dipeptidyl peptidase 4 | ||
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 88271.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50137251 | |||
| n/a | |||
| Name | BDBM50137251 | ||
| Synonyms: | CHEMBL264738 | N-(4-((S)-1-amino-2-oxo-2-(pyrrolidin-1-yl)ethyl)cyclohexyl)-2,4-difluorobenzenesulfonamide | N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-2,4-difluoro-benzenesulfonamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H25F2N3O3S | ||
| Mol. Mass. | 401.471 | ||
| SMILES | N[C@@H](C1CC[C@@H](CC1)NS(=O)(=O)c1ccc(F)cc1F)C(=O)N1CCCC1 |r,wU:1.0,wD:5.8,(27.95,-4.24,;28,-2.7,;26.69,-1.89,;25.33,-2.62,;24.02,-1.8,;24.08,-.26,;25.44,.46,;26.74,-.35,;22.77,.55,;21.41,-.17,;20.67,1.18,;22.15,-1.52,;20.07,-.93,;18.74,-.13,;17.4,-.89,;17.38,-2.43,;16.04,-3.19,;18.72,-3.22,;20.05,-2.46,;21.38,-3.24,;29.35,-1.97,;29.4,-.43,;30.66,-2.78,;31.13,-4.25,;32.67,-4.25,;33.15,-2.78,;31.9,-1.87,)| | ||
| Structure | 
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