| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin releasing hormone receptor 2 |
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| Ligand | BDBM50158983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_572724 (CHEMBL1030148) |
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| IC50 | 0.58±n/a nM |
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| Citation |  Hartz, RA; Ahuja, VT; Rafalski, M; Schmitz, WD; Brenner, AB; Denhart, DJ; Ditta, JL; Deskus, JA; Yue, EW; Arvanitis, AG; Lelas, S; Li, YW; Molski, TF; Wong, H; Grace, JE; Lentz, KA; Li, J; Lodge, NJ; Zaczek, R; Combs, AP; Olson, RE; Mattson, RJ; Bronson, JJ; Macor, JE In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. J Med Chem52:4161-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin releasing hormone receptor 2 |
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| Name: | Corticotropin releasing hormone receptor 2 |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47765.85 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_572724 |
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| Residue: | 411 |
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| Sequence: | MDAALLHSLLEANCSLALAEELLLDGWGMSLDPEGRYFYCNTTLDQIGTCWPRSAAGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRINYSQCEPILDDKQRKYDLHYRIALVVN
YLGHCVSVAALVAAFLIFLALRSIRCLRNVIHWNLIATFILRNVLWFLLQLIDHEVHESN
EVWCRCITTVFNYFVVTNFFWMFAEGCYLHTAIVMTYSTERLRKWLFLFIGWCVPCPIII
AWAIGKLYYENKQCWFGKEPGDLVDYIYQGPIILVLLINFIFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVSPGEDELSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRAAVRKRWHRWQDHHSLRVPVARAMSIPTSPTRISFHSIKQTAAV
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| BDBM50158983 |
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| n/a |
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| Name | BDBM50158983 |
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| Synonyms: | CHEMBL439883 | E G P P I S I D L S L E L L R K M I E I E K Q E K E K Q Q A A N N R L L L D T I-NH2(Sauvagine) | SAUVAGINE |
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| Type | Small organic molecule |
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| Emp. Form. | C202H345N55O64S |
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| Mol. Mass. | 4600.296 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O |
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| Structure | 
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