Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50248955 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_578681 (CHEMBL1063062) |
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Ki | 3.07±n/a nM |
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Citation | Zampieri, D; Mamolo, MG; Laurini, E; Florio, C; Zanette, C; Fermeglia, M; Posocco, P; Paneni, MS; Pricl, S; Vio, L Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. J Med Chem52:5380-93 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25266.54 |
Organism: | RAT |
Description: | Q9R0C9 |
Residue: | 223 |
Sequence: | MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRY
WAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
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BDBM50248955 |
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n/a |
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Name | BDBM50248955 |
Synonyms: | 3-((1-(4-methylbenzyl)piperidin-4-yl)methyl)benzo[d]oxazol-2(3H)-one | 3-[[1-(4-Methylbenzyl)piperidin-4-yl]methyl]benzo[d]oxazol-2(3H)-one | CHEMBL474565 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O2 |
Mol. Mass. | 336.4275 |
SMILES | Cc1ccc(CN2CCC(Cn3c4ccccc4oc3=O)CC2)cc1 |
Structure |
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