| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM50296960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580941 (CHEMBL1054906) |
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| EC50 | 0.230000±n/a nM |
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| Citation |  Hattori, K; Orita, M; Toda, S; Imanishi, M; Itou, S; Nakajima, Y; Tanabe, D; Washizuka, K; Araki, T; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6. Bioorg Med Chem Lett19:4679-83 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43534.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 408 |
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| Sequence: | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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| BDBM50296960 |
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| n/a |
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| Name | BDBM50296960 |
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| Synonyms: | (R)-4'-(2-(2-(6-acetamidopyridin-3-yl)-2-hydroxyethylamino)ethyl)-3-(cyclohexyloxy)-N-(methylsulfonyl)biphenyl-4-carboxamide | CHEMBL559334 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H38N4O6S |
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| Mol. Mass. | 594.722 |
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| SMILES | CC(=O)Nc1ccc(cn1)[C@@H](O)CNCCc1ccc(cc1)-c1ccc(C(=O)NS(C)(=O)=O)c(OC2CCCCC2)c1 |r| |
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| Structure | 
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