| Reaction Details |
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 | Report a problem with these data |
| Target | B-cell receptor CD22 |
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| Ligand | BDBM50378465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599602 (CHEMBL1040214) |
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| IC50 | 305200±n/a nM |
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| Citation |  Abdu-Allah, HH; Watanabe, K; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Tsubata, T; Ishida, H; Kiso, M Potent small molecule mouse CD22-inhibitors: exploring the interaction of the residue at C-2 of sialic acid scaffold. Bioorg Med Chem Lett19:5573-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B-cell receptor CD22 |
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| Name: | B-cell receptor CD22 |
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| Synonyms: | B-lymphocyte cell adhesion molecule | BL-CAM | CD22_MOUSE | CD_antigen=CD22 | Cd22 | Lyb-8 | Sialic acid-binding Ig-like lectin 2 | Siglec-2 | Siglec2 | T-cell surface antigen Leu-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96597.27 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_727025 |
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| Residue: | 862 |
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| Sequence: | MRVHYLWLLLILGHAASAQYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNI
LLFQNYEFDKATKKFKGTVLYNKAEPELYPPKQRRVTFLGNSIDNCTLKIHPIRANDSGN
LGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFEYDILLQW
FLEDSKITSVTPSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSEVLSE
RTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQEL
EQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEE
GQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHG
KIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVL
KPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRV
LLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAW
NLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLR
LEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWG
MKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAIL
RFPESDMHNAGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSEL
VQFGAGKRPQAKEDVDYVTLKH
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| BDBM50378465 |
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| n/a |
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| Name | BDBM50378465 |
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| Synonyms: | CHEMBL569217 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H35NO16 |
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| Mol. Mass. | 593.5318 |
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| SMILES | COc1ccc(O[C@@H]2O[C@H](CO[C@@]3(C[C@H](O)[C@H](NC(=O)CO)[C@@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)[C@H](O)[C@H](O)[C@H]2O)cc1 |r| |
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| Structure | 
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