| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor IX |
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| Ligand | BDBM50307319 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610633 (CHEMBL1069647) |
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| Ki | 75±n/a nM |
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| Citation |  Wang, S; Beck, R; Blench, T; Burd, A; Buxton, S; Malic, M; Ayele, T; Shaikh, S; Chahwala, S; Chander, C; Holland, R; Merette, S; Zhao, L; Blackney, M; Watts, A Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem53:1465-72 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor IX |
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| Name: | Coagulation factor IX |
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| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
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| Type: | Enzyme |
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| Mol. Mass.: | 51768.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00740 |
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| Residue: | 461 |
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| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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| BDBM50307319 |
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| n/a |
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| Name | BDBM50307319 |
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| Synonyms: | 6-(4-Chloro-3-fluoro-benzyloxy)-benzo[b]thiophene-2-carboxamidine | CHEMBL596766 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16ClFN2OS |
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| Mol. Mass. | 410.892 |
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| SMILES | NC(=N)c1cc2cc(ccc2s1)-c1cccc(OCc2ccc(Cl)c(F)c2)c1 |
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| Structure | 
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