| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
|---|
| Ligand | BDBM50378626 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_610636 (CHEMBL1069650) |
|---|
| IC50 | 1442±n/a nM |
|---|
| Citation |  Wu, Y; Tai, HH; Cho, H Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. Bioorg Med Chem18:1428-33 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
|---|
| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
|---|
| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28974.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15428 |
|---|
| Residue: | 266 |
|---|
| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
|
|
|
|---|
| BDBM50378626 |
|---|
| n/a |
|---|
| Name | BDBM50378626 |
|---|
| Synonyms: | CHEMBL599416 | US8637558, 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H20N2O3S |
|---|
| Mol. Mass. | 332.417 |
|---|
| SMILES | OC1=NC(=O)C(S1)=Cc1ccc(OCCN2CCCCC2)cc1 |w:7.8,t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
