| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aromatase |
|---|
| Ligand | BDBM50307911 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_612867 (CHEMBL1067556) |
|---|
| IC50 | 4.6±n/a nM |
|---|
| Citation |  Woo, LW; Jackson, T; Putey, A; Cozier, G; Leonard, P; Acharya, KR; Chander, SK; Purohit, A; Reed, MJ; Potter, BV Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem53:2155-70 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aromatase |
|---|
| Name: | Aromatase |
|---|
| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57888.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11511 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
|
|
|
|---|
| BDBM50307911 |
|---|
| n/a |
|---|
| Name | BDBM50307911 |
|---|
| Synonyms: | 4-((1H-1,2,4-triazol-1-yl)methyl)biphenyl-2-carbonitrile | CHEMBL608153 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12N4 |
|---|
| Mol. Mass. | 260.2933 |
|---|
| SMILES | N#Cc1cc(Cn2cncn2)ccc1-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
