| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50307917 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612867 (CHEMBL1067556) |
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| IC50 | 6±n/a nM |
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| Citation |  Woo, LW; Jackson, T; Putey, A; Cozier, G; Leonard, P; Acharya, KR; Chander, SK; Purohit, A; Reed, MJ; Potter, BV Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem53:2155-70 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
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| Type: | Enzyme |
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| Mol. Mass.: | 57888.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11511 |
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| Residue: | 503 |
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| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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| BDBM50307917 |
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| n/a |
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| Name | BDBM50307917 |
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| Synonyms: | 2-(5-((1H-1,2,4-triazol-1-yl)methyl)-4'-hydroxybiphenyl-3-yl)-2-methylpropanenitrile | CHEMBL605418 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N4O |
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| Mol. Mass. | 318.3724 |
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| SMILES | CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)-c1ccc(O)cc1 |
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| Structure | 
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