| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 6 |
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| Ligand | BDBM50314804 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627226 (CHEMBL1110795) |
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| EC50 | 99000±n/a nM |
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| Citation |  Selvam, C; Oueslati, N; Lemasson, IA; Brabet, I; Rigault, D; Courtiol, T; Cesarini, S; Triballeau, N; Bertrand, HO; Goudet, C; Pin, JP; Acher, FC A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. J Med Chem53:2797-813 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 6 |
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| Name: | Metabotropic glutamate receptor 6 |
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| Synonyms: | GRM6_RAT | Gprc1f | Grm6 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 6 (mGlu6) | Mglur6 | mGlu6 | metabotropic glutamate 6 |
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| Type: | Enzyme |
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| Mol. Mass.: | 95095.82 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P35349 |
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| Residue: | 871 |
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| Sequence: | MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGV
HRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEA
SVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTR
YDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIA
QSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGS
DSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFN
CKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGH
TGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGG
YQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGY
RFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMAT
FMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYS
ALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVID
YEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIG
FTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFH
PEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
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| BDBM50314804 |
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| n/a |
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| Name | BDBM50314804 |
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| Synonyms: | (R)-3-amino-3-carboxypropyl-2'-carboxyethyl phosphinic acid | CHEMBL1089514 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H14NO6P |
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| Mol. Mass. | 239.1629 |
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| SMILES | N[C@H](CCP(O)(=O)CCC(O)=O)C(O)=O |r| |
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| Structure | 
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