| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Ligand | BDBM50316067 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_623313 (CHEMBL1115236) |
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| IC50 | 28100±n/a nM |
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| Citation |  North, EJ; Howard, AL; Wanjala, IW; Pham, TC; Baker, DL; Parrill, AL Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors. J Med Chem53:3095-105 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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| Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 99007.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13822 |
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| Residue: | 863 |
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| Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
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| BDBM50316067 |
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| n/a |
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| Name | BDBM50316067 |
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| Synonyms: | 4-amino-6-((4'-((7-amino-1-hydroxy-3-sulfonaphthalen-2-yl)diazenyl)biphenyl-4-yl)diazenyl)-5-hydroxy-3-((3-nitrophenyl)diazenyl)naphthalene-2,7-disulfonic acid | CHEMBL1092081 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H27N9O13S3 |
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| Mol. Mass. | 913.868 |
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| SMILES | Nc1ccc2cc(c(N=Nc3ccc(cc3)-c3ccc(cc3)N=Nc3c(O)c4c(N)c(N=Nc5cccc(c5)[N+]([O-])=O)c(cc4cc3S(O)(=O)=O)S(O)(=O)=O)c(O)c2c1)S(O)(=O)=O |w:9.9,31.32,23.25| |
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| Structure | 
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