| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 [K65Q] |
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| Ligand | BDBM50320783 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639163 (CHEMBL1167424) |
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| IC50 | 8300±n/a nM |
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| Citation |  Maccari, R; Ciurleo, R; Giglio, M; Cappiello, M; Moschini, R; Corso, AD; Mura, U; Ottanà, R Identification of new non-carboxylic acid containing inhibitors of aldose reductase. Bioorg Med Chem18:4049-55 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 [K65Q] |
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| Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
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| Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
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| Type: | Protein |
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| Mol. Mass.: | 35916.27 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P16116[K65Q] |
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| Residue: | 315 |
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| Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
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| BDBM50320783 |
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| n/a |
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| Name | BDBM50320783 |
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| Synonyms: | (Z)-5-(4-phenoxybenzylidene)-3-(3,3,3-trifluoro-2,2-dihydroxypropyl)thiazolidine-2,4-dione | CHEMBL1165383 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14F3NO5S |
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| Mol. Mass. | 425.378 |
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| SMILES | OC(O)(CN1C(=O)S\C(=C/c2ccc(Oc3ccccc3)cc2)C1=O)C(F)(F)F |
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| Structure | 
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