Reaction Details |
| Report a problem with these data |
Target | Orexin/Hypocretin receptor type 1 |
---|
Ligand | BDBM50321511 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_639601 (CHEMBL1175134) |
---|
Ki | 0.9±n/a nM |
---|
Citation | Coleman, PJ; Schreier, JD; Roecker, AJ; Mercer, SP; McGaughey, GB; Cox, CD; Hartman, GD; Harrell, CM; Reiss, DR; Doran, SM; Garson, SL; Anderson, WB; Tang, C; Prueksaritanont, T; Winrow, CJ; Renger, JJ Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat. Bioorg Med Chem Lett20:4201-5 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin/Hypocretin receptor type 1 |
---|
Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
|
|
|
BDBM50321511 |
---|
n/a |
---|
Name | BDBM50321511 |
Synonyms: | (+/-)-(9-(7-fluoroquinazolin-2-yl)-3,9-diazabicyclo[4.2.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | CHEMBL1170803 |
Type | Small organic molecule |
Emp. Form. | C25H24FN7O |
Mol. Mass. | 457.5028 |
SMILES | Cc1ccc(c(c1)C(=O)N1CCC2CCC(C1)N2c1ncc2ccc(F)cc2n1)-n1nccn1 |
Structure |
|