Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50342041 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_743741 (CHEMBL1767555) |
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Ki | 75.2±n/a nM |
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Citation | Donohue, SR; Dannals, RF; Halldin, C; Pike, VW N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. J Med Chem54:2961-70 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50342041 |
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n/a |
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Name | BDBM50342041 |
Synonyms: | 1-(2-Bromophenyl)-N-(1-cyanocyclohexyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide | CHEMBL1765676 |
Type | Small organic molecule |
Emp. Form. | C24H23BrN4O |
Mol. Mass. | 463.37 |
SMILES | Cc1c(nn(c1-c1ccccc1)-c1ccccc1Br)C(=O)NC1(CCCCC1)C#N |
Structure |
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