Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0726 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0726 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from rat PBR receptor | J Med Chem 52: 688-99 (2009) Article DOI: 10.1021/jm8011855 BindingDB Entry DOI: 10.7270/Q2HX1CJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50258612 (3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400876 (CHEMBL2204347) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50229593 (CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.0978 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400875 (CHEMBL2204353) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.101 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400874 (CHEMBL2086410) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.106 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400873 (CHEMBL2088029) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400872 (CHEMBL2088033) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50255877 (CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from rat PBR receptor | J Med Chem 52: 688-99 (2009) Article DOI: 10.1021/jm8011855 BindingDB Entry DOI: 10.7270/Q2HX1CJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327858 ((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327865 ((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.215 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400871 (CHEMBL2088030) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.231 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.242 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in human mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293 (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.242 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from human PBR receptor | J Med Chem 52: 688-99 (2009) Article DOI: 10.1021/jm8011855 BindingDB Entry DOI: 10.7270/Q2HX1CJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336827 (3-[(2-Aminothiazol)-4-ethynyl]-5-fluorobenzonitril...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50400870 (CHEMBL559569 | SB-612111) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.253 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by microbeta scintillation counting | J Med Chem 54: 2687-700 (2011) Article DOI: 10.1021/jm101487v BindingDB Entry DOI: 10.7270/Q20V8DXB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336830 (3-((2-Chlorothiazol)-4-yl)ethynyl)benzonitrile | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50335260 (CHEMBL1651226 | N,N-dihexyl-2-(1-methyl-2-phenyl-1...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.299 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50335259 (CHEMBL1651225 | N,N-dibutyl-2-(1-methyl-2-phenyl-1...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50253862 ((-)-3-(4-Chlorophenyl)-N'-[(4-iodophenyl)sulfonyl]...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assay | J Med Chem 51: 5608-16 (2008) Article DOI: 10.1021/jm800329z BindingDB Entry DOI: 10.7270/Q2GT5N00 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327863 ((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.334 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327864 ((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.334 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22038 (2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexyl-2...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PBR28 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM21278 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assay | J Med Chem 51: 5608-16 (2008) Article DOI: 10.1021/jm800329z BindingDB Entry DOI: 10.7270/Q2GT5N00 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50383117 (CHEMBL2031737) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human H3 receptor | J Med Chem 55: 2406-15 (2012) Article DOI: 10.1021/jm201690h BindingDB Entry DOI: 10.7270/Q2BR8T6Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336831 (3-((2-Chlorothiazol)-4-yl)ethynyl)-5-fluorobenzoni...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327859 ((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50060095 (2-[6,8-Dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50253826 ((-)-3-(4-Chlorophenyl)-N'-[(4-cyanophenyl)sulfonyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assay | J Med Chem 51: 5608-16 (2008) Article DOI: 10.1021/jm800329z BindingDB Entry DOI: 10.7270/Q2GT5N00 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327860 ((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.577 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50253754 (4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from mu opioid receptor | J Med Chem 51: 6034-43 (2008) Article DOI: 10.1021/jm800510m BindingDB Entry DOI: 10.7270/Q2BV7GFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50229594 (CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50229596 (1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in Sprague-Dawley rat mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327861 ((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.738 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50253754 (4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]Pentazocine from rat sigma 1 receptor in rat PC12 cells | J Med Chem 51: 6034-43 (2008) Article DOI: 10.1021/jm800510m BindingDB Entry DOI: 10.7270/Q2BV7GFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336826 (3-[(2-Aminothiazol)-4-ethynyl]benzonitrile | CHEMB...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM50327862 ((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.901 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | J Med Chem 53: 7035-47 (2010) Article DOI: 10.1021/jm100668r BindingDB Entry DOI: 10.7270/Q2BR8SD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336835 (3-((2-Bromothiazol)-4-ethynyl)-5-fluorobenzonitril...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50255877 (CHEMBL473435 | N-Fluoroacetyl-N-(2,5-dimethoxybenz...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.997 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from human PBR receptor | J Med Chem 52: 688-99 (2009) Article DOI: 10.1021/jm8011855 BindingDB Entry DOI: 10.7270/Q2HX1CJP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50253754 (4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [125I]HEAT from adrenergic alpha2A receptor | J Med Chem 51: 6034-43 (2008) Article DOI: 10.1021/jm800510m BindingDB Entry DOI: 10.7270/Q2BV7GFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM35229 (3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institutet Curated by ChEMBL | Assay Description Binding affinity at NET | Bioorg Med Chem 15: 616-25 (2006) Article DOI: 10.1016/j.bmc.2006.10.065 BindingDB Entry DOI: 10.7270/Q22B8XPV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Rattus norvegicus (rat)) | BDBM50383118 (CHEMBL2031738) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to rat H3 receptor | J Med Chem 55: 2406-15 (2012) Article DOI: 10.1021/jm201690h BindingDB Entry DOI: 10.7270/Q2BR8T6Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM22032 (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]PK11195 from TSPO receptor in rat kidney membranes | J Med Chem 54: 2961-70 (2011) Article DOI: 10.1021/jm2000536 BindingDB Entry DOI: 10.7270/Q2KS6SJS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Translocator protein (Rattus norvegicus (rat)) | BDBM50335268 (2-(2-(4-fluorophenyl)-1-methyl-1H-indol-3-yl)-N,N-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from TSPO in rat kidney mitochondrial membrane | J Med Chem 54: 366-73 (2011) Article DOI: 10.1021/jm101230g BindingDB Entry DOI: 10.7270/Q2ZC83T4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50253754 (4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from dopamine D4 receptor | J Med Chem 51: 6034-43 (2008) Article DOI: 10.1021/jm800510m BindingDB Entry DOI: 10.7270/Q2BV7GFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50336839 (3-((2-Iodothiazol)-4-ethynyl)-5-fluorobenzonitrile...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain | J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50229593 (CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Mental Health Curated by ChEMBL | Assay Description Binding affinity to PBR in human mitochondrial tissue | J Med Chem 51: 17-30 (2008) Article DOI: 10.1021/jm0707370 BindingDB Entry DOI: 10.7270/Q2N58M32 | |||||||||||
More data for this Ligand-Target Pair |
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