BindingDB PrimarySearch

BDBM50336843 3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile::CHEMBL1672288

SMILES: Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N

InChI Key: InChIKey=LVXAMCKZCLWWTF-UHFFFAOYSA-N

Data: 47 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50336843
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to sigma 1 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic beta2 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT1A receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT1B receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT1D receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT1E receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT2A receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT2B receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT2C receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT3 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT5A receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT6 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to 5HT7 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha1A receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic alpha1B (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic Alpha-1B receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic Alpha-1D receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha2A receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic Alpha-2C receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic beta1 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic beta3 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to dopamine D1 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to dopamine D2 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to dopamine D3 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to dopamine D4 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to dopamine D5 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to DAT				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to KOR				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H1 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 Receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H2 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H3 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H4 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to muscarinic M1 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to muscarinic M2 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to muscarinic M3 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to muscarinic M4 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to muscarinic M5 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to mGluR1 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to mGluR2 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to mGluR4 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to mGluR6 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
GRM8 (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to mGluR8 receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to MOR				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to NET				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to SERT receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to DOR				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2B adrenergic receptor (Homo sapiens (Human))	BDBM50336843 (3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...) Show SMILES Fc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha2B receptor				J Med Chem 54: 901-8 (2012) Article DOI: 10.1021/jm101430m BindingDB Entry DOI: 10.7270/Q26Q1Z7T
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair