| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase I, thermostable |
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| Ligand | BDBM50356642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_785415 (CHEMBL1919794) |
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| IC50 | >100000±n/a nM |
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| Citation |  Maruo, S; Kuriyama, I; Kuramochi, K; Tsubaki, K; Yoshida, H; Mizushina, Y Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Bioorg Med Chem19:5803-12 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase I, thermostable |
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| Name: | DNA polymerase I, thermostable |
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| Synonyms: | DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93906.95 |
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| Organism: | Thermus aquaticus |
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| Description: | ChEMBL_1289218 |
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| Residue: | 832 |
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| Sequence: | MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
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| BDBM50356642 |
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| n/a |
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| Name | BDBM50356642 |
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| Synonyms: | CHEMBL1917196 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28O4 |
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| Mol. Mass. | 356.4553 |
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| SMILES | CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12 |c:21| |
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| Structure | 
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