Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153106 (CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153111 (CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50379292 (CHEMBL2011646) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy... | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153113 (CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153111 (CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibition constant against DNA polymerase alpha competitively on DNA template | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50379292 (CHEMBL2011646) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate... | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153106 (CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibition constant against DNA polymerase alpha competitively on DNA template | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153113 (CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.79E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibition constant against DNA polymerase alpha competitively on DNA template | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit B (Bos taurus (bovine)) | BDBM33388 (dehydroaltenusin derivative, 16) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit B (Bos taurus (bovine)) | BDBM33387 (dehydroaltenusin derivative, 15) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit B (Bos taurus (bovine)) | BDBM33386 (dehydroaltenusin derivative, 14) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit B (Bos taurus (bovine)) | BDBM33389 (dehydroaltenusin derivative, 20) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit B (Bos taurus (bovine)) | BDBM33384 (dehydroaltenusin) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha subunit B (Bos taurus (bovine)) | BDBM33385 (desmethyldehydroaltenusin, 2) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 890 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA nucleotidylexotransferase (Homo sapiens (Human)) | BDBM50143524 ((3aR,4R,7R,7aS)-3,5-Dihexadecyl-3a,4,7,7a-tetrahyd...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibitory activity of the compound against human terminal deoxynucleotidyltransferase | Bioorg Med Chem Lett 14: 1975-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.092 BindingDB Entry DOI: 10.7270/Q2W095C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50356642 (CHEMBL1917196) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase eta (Homo sapiens (Human)) | BDBM50356642 (CHEMBL1917196) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged human DNA polymerase eta (amino acids 1 to 511) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA templ... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase lambda (Homo sapiens (Human)) | BDBM50356642 (CHEMBL1917196) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase iota (Mus musculus) | BDBM50356642 (CHEMBL1917196) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged mouse DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleot... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50356642 (CHEMBL1917196) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-directed DNA/RNA polymerase mu (Homo sapiens (Human)) | BDBM50356642 (CHEMBL1917196) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of His-tagged human DNA polymerase mu using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate ... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153113 (CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50356643 (CHEMBL1917198) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase eta (Homo sapiens (Human)) | BDBM50356643 (CHEMBL1917198) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged human DNA polymerase eta (amino acids 1 to 511) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA templ... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA nucleotidylexotransferase (Bos taurus) | BDBM50356642 (CHEMBL1917196) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of calf thymus TdT using oligo(dT)18 (3'-OH) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase iota (Mus musculus) | BDBM50356643 (CHEMBL1917198) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged mouse DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleot... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase lambda (Homo sapiens (Human)) | BDBM50356643 (CHEMBL1917198) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-directed DNA/RNA polymerase mu (Homo sapiens (Human)) | BDBM50356643 (CHEMBL1917198) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of His-tagged human DNA polymerase mu using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate ... | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50153117 ((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 units | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM33388 (dehydroaltenusin derivative, 16) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50356643 (CHEMBL1917198) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA nucleotidylexotransferase (Bos taurus) | BDBM50356643 (CHEMBL1917198) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Prefectural University Curated by ChEMBL | Assay Description Inhibition of calf thymus TdT using oligo(dT)18 (3'-OH) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins | Bioorg Med Chem 19: 5803-12 (2011) Article DOI: 10.1016/j.bmc.2011.08.023 BindingDB Entry DOI: 10.7270/Q2DZ0989 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50375301 (CHEMBL260980) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition of rat DNA polymerase beta | Bioorg Med Chem 16: 2939-44 (2008) Article DOI: 10.1016/j.bmc.2007.12.044 BindingDB Entry DOI: 10.7270/Q2J67HST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA nucleotidylexotransferase (Homo sapiens (Human)) | BDBM50143526 (CHEMBL366792 | Untenone A) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibitory activity of the compound against human terminal deoxynucleotidyltransferase | Bioorg Med Chem Lett 14: 1975-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.092 BindingDB Entry DOI: 10.7270/Q2W095C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50375300 (TALAROFLAVONE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition of rat DNA polymerase beta | Bioorg Med Chem 16: 2939-44 (2008) Article DOI: 10.1016/j.bmc.2007.12.044 BindingDB Entry DOI: 10.7270/Q2J67HST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA nucleotidylexotransferase (Homo sapiens (Human)) | BDBM50143528 ((1S,2S)-2-Hexadecyl-2-methoxymethoxy-5-oxo-cyclope...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibitory activity of the compound against human terminal deoxynucleotidyltransferase | Bioorg Med Chem Lett 14: 1975-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.092 BindingDB Entry DOI: 10.7270/Q2W095C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153111 (CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM33387 (dehydroaltenusin derivative, 15) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50251277 (CHEMBL458178 | Kasanosin A) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.73E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition of rat DNA polymerase beta | Bioorg Med Chem 16: 4594-9 (2008) Article DOI: 10.1016/j.bmc.2008.02.037 BindingDB Entry DOI: 10.7270/Q2X066TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153106 (CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase subunit gamma-1 (Homo sapiens (Human)) | BDBM50251277 (CHEMBL458178 | Kasanosin A) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase gamma | Bioorg Med Chem 16: 4594-9 (2008) Article DOI: 10.1016/j.bmc.2008.02.037 BindingDB Entry DOI: 10.7270/Q2X066TH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM33386 (dehydroaltenusin derivative, 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Kyoto Prefectural University | Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f... | Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50153117 ((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Frontier Research Center for Genome & Drug Discovery Curated by ChEMBL | Assay Description Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units | J Med Chem 47: 4971-4 (2004) Article DOI: 10.1021/jm030553v BindingDB Entry DOI: 10.7270/Q2RN37BH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50379292 (CHEMBL2011646) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po... | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase iota (Mus musculus) | BDBM50379292 (CHEMBL2011646) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 ... | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase nu (Homo sapiens (Human)) | BDBM50379292 (CHEMBL2011646) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Inhibition of C-terminal-His6-tagged human pol nu expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(d... | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase delta catalytic subunit (Homo sapiens (Human)) | BDBM50379292 (CHEMBL2011646) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50379293 (CHEMBL2011648) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Science University of Tokyo Curated by ChEMBL | Assay Description Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po... | J Nat Prod 75: 135-41 (2012) Article DOI: 10.1021/np200523b BindingDB Entry DOI: 10.7270/Q2T154NG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase kappa (Homo sapiens (Human)) | BDBM50375301 (CHEMBL260980) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase kappa | Bioorg Med Chem 16: 2939-44 (2008) Article DOI: 10.1016/j.bmc.2007.12.044 BindingDB Entry DOI: 10.7270/Q2J67HST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50251278 (CHEMBL457091 | Kasanosin B) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition of rat DNA polymerase beta | Bioorg Med Chem 16: 4594-9 (2008) Article DOI: 10.1016/j.bmc.2008.02.037 BindingDB Entry DOI: 10.7270/Q2X066TH | |||||||||||
More data for this Ligand-Target Pair |
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