| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50379231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_811227 (CHEMBL2015062) |
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| IC50 | 758.58±n/a nM |
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| Citation |  Cisneros, JA; Björklund, E; González-Gil, I; Hu, Y; Canales, A; Medrano, FJ; Romero, A; Ortega-Gutiérrez, S; Fowler, CJ; López-Rodríguez, ML Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors. J Med Chem55:824-36 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50379231 |
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| n/a |
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| Name | BDBM50379231 |
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| Synonyms: | CHEMBL2011319 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22O3 |
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| Mol. Mass. | 322.3976 |
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| SMILES | O=C(OCC1CCCCO1)\C=C\c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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