Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50379356 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_811982 (CHEMBL2013352) |
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IC50 | 29±n/a nM |
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Citation | Wang, T; Block, MA; Cowen, S; Davies, AM; Devereaux, E; Gingipalli, L; Johannes, J; Larsen, NA; Su, Q; Tucker, JA; Whitston, D; Wu, J; Zhang, HJ; Zinda, M; Chuaqui, C Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKe kinases. Bioorg Med Chem Lett22:2063-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50379356 |
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n/a |
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Name | BDBM50379356 |
Synonyms: | CHEMBL2011932 |
Type | Small organic molecule |
Emp. Form. | C21H25BrN6O2 |
Mol. Mass. | 473.366 |
SMILES | COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3(CN)CC3)c2[nH]1 |
Structure |
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