| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Ligand | BDBM50381579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814690 (CHEMBL2021209) |
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| IC50 | 300±n/a nM |
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| Citation |  Harada, K; Kubo, H; Abe, J; Haneta, M; Conception, A; Inoue, S; Okada, S; Nishioka, K Discovery of potent and orally bioavailable 17ß-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg Med Chem20:3242-54 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Synonyms: | 17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34525.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37058 |
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| Residue: | 310 |
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| Sequence: | MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
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| BDBM50381579 |
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| n/a |
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| Name | BDBM50381579 |
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| Synonyms: | CHEMBL2018229 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17BrN2O6 |
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| Mol. Mass. | 473.273 |
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| SMILES | Oc1ccc(\C=C2/OC(=O)N(C2=O)c2ccc(cc2)C(=O)N2CCOCC2)cc1Br |
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| Structure | 
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