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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(3) dopamine receptor | ||
| Ligand | BDBM50382297 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_816863 (CHEMBL2026134) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett22:3437-40 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(3) dopamine receptor | |||
| Name: | D(3) dopamine receptor | ||
| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 49540.58 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | P19020 | ||
| Residue: | 446 | ||
| Sequence: |
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| BDBM50382297 | |||
| n/a | |||
| Name | BDBM50382297 | ||
| Synonyms: | CHEMBL2024511 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H32F3N3O2S | ||
| Mol. Mass. | 447.558 | ||
| SMILES | CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(Cc3cccc(c3)C(F)(F)F)CC2)CC1 |r,wU:5.4,wD:8.8,(-11.08,-24.94,;-9.74,-24.17,;-8.97,-22.83,;-10.51,-22.84,;-8.41,-24.94,;-7.08,-24.17,;-7.08,-22.63,;-5.75,-21.85,;-4.42,-22.63,;-3.08,-21.86,;-1.75,-22.63,;-.42,-21.87,;.91,-22.65,;2.24,-21.89,;2.25,-20.35,;3.59,-19.59,;4.92,-20.36,;6.26,-19.6,;7.59,-20.38,;7.58,-21.91,;6.25,-22.68,;4.91,-21.91,;6.25,-24.22,;4.92,-24.99,;7.59,-24.99,;6.27,-25.77,;.92,-19.57,;-.42,-20.33,;-4.42,-24.17,;-5.75,-24.93,)| | ||
| Structure | 
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