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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(2) dopamine receptor | ||
| Ligand | BDBM50382292 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_816864 (CHEMBL2026135) | ||
| IC50 | 135±n/a nM | ||
| Citation |  Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett22:3437-40 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(2) dopamine receptor | |||
| Name: | D(2) dopamine receptor | ||
| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 50931.60 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P61169 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50382292 | |||
| n/a | |||
| Name | BDBM50382292 | ||
| Synonyms: | CHEMBL2024509 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H29F3N4O2S | ||
| Mol. Mass. | 458.541 | ||
| SMILES | CS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cc(cc(c2)C(F)(F)F)C#N)CC1 |r,wU:5.4,wD:8.8,(10.58,-4.56,;11.92,-3.78,;12.68,-2.45,;11.14,-2.45,;13.25,-4.55,;14.58,-3.78,;14.58,-2.24,;15.91,-1.46,;17.24,-2.24,;18.58,-1.47,;19.91,-2.25,;21.24,-1.48,;22.57,-2.26,;23.9,-1.5,;23.91,.04,;22.58,.82,;21.24,.05,;25.25,.8,;26.58,.02,;27.92,.78,;27.93,2.32,;26.59,3.1,;25.26,2.33,;26.6,4.64,;27.93,5.4,;25.27,5.41,;26.58,6.18,;29.25,0,;30.57,-.78,;17.24,-3.78,;15.91,-4.54,)| | ||
| Structure | 
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