Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50382302

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_816864 (CHEMBL2026135)

IC50

7.1±n/a nM

Citation

Agai-Csongor, E; Domány, G; Nógrádi, K; Galambos, J; Vágó, I; Keseru, GM; Greiner, I; Laszlovszky, I; Gere, A; Schmidt, E; Kiss, B; Vastag, M; Tihanyi, K; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Kapás, M; Szombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett22:3437-40 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

50931.60

Organism:

Rattus norvegicus (rat)

Description:

P61169

Residue:

444

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC

BDBM50382302

n/a

Name

BDBM50382302

Synonyms:

CHEMBL2024516

Type

Small organic molecule

Emp. Form.

C21H31Cl2N3O

Mol. Mass.

412.396

SMILES

CCC(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |r,wU:5.4,wD:8.8,(-5.5,-6.61,;-4.16,-7.38,;-2.83,-6.61,;-2.83,-5.07,;-1.5,-7.38,;-.16,-6.61,;-.16,-5.07,;1.17,-4.29,;2.49,-5.07,;3.83,-4.31,;5.16,-5.08,;6.5,-4.31,;7.82,-5.09,;9.16,-4.33,;9.17,-2.79,;7.84,-2.01,;6.49,-2.78,;10.5,-2.02,;11.85,-2.77,;13.18,-1.97,;13.14,-.43,;11.8,.31,;11.77,1.85,;10.48,-.49,;9.13,.26,;2.49,-6.61,;1.17,-7.37,)|

Structure