| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50319665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814879 (CHEMBL2026621) |
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| Ki | 70.8±n/a nM |
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| Citation |  Li, A; Yuan, CC; Chow, D; Chen, M; Emery, MG; Hale, C; Zhang, X; Subramanian, R; St Jean, DJ; Komorowski, R; Véniant, M; Wang, M; Fotsch, C Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes. ACS Med Chem Lett2:824-827 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32369.70 |
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| Organism: | Mus musculus (mouse) |
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| Description: | P50172 |
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| Residue: | 292 |
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| Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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| BDBM50319665 |
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| n/a |
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| Name | BDBM50319665 |
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| Synonyms: | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one | AMG-221 | CHEMBL1085107 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H22N2OS |
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| Mol. Mass. | 266.402 |
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| SMILES | CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O |r,c:16| |
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| Structure | 
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