| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
|---|
| Ligand | BDBM50383344 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_820157 (CHEMBL2033868) |
|---|
| EC50 | 126±n/a nM |
|---|
| Citation |  Cid, JM; Duvey, G; Tresadern, G; Nhem, V; Furnari, R; Cluzeau, P; Vega, JA; de Lucas, AI; Matesanz, E; Alonso, JM; Linares, ML; Andrés, JI; Poli, SM; Lutjens, R; Himogai, H; Rocher, JP; Macdonald, GJ; Oehlrich, D; Lavreysen, H; Ahnaou, A; Drinkenburg, W; Mackie, C; Trabanco, AA Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. J Med Chem55:2388-405 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 2 |
|---|
| Name: | Metabotropic glutamate receptor 2 |
|---|
| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 95584.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14416 |
|---|
| Residue: | 872 |
|---|
| Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
|
|
|
|---|
| BDBM50383344 |
|---|
| n/a |
|---|
| Name | BDBM50383344 |
|---|
| Synonyms: | CHEMBL2029806 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21N3O2 |
|---|
| Mol. Mass. | 371.4317 |
|---|
| SMILES | Cc1cc(Oc2ccc(cc2)-c2ccn(CC3CCC3)c(=O)c2C#N)ccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
