| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50384691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820804 (CHEMBL2038509) |
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| EC50 | 15±n/a nM |
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| Citation |  Harrington, PE; Croghan, MD; Fotsch, C; Frohn, M; Lanman, BA; Pennington, LD; Pickrell, AJ; Reed, AB; Sham, KK; Tasker, A; Arnett, HA; Fiorino, M; Lee, MR; McElvain, M; Morrison, HG; Xu, H; Xu, Y; Zhang, X; Wong, M; Cee, VJ Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett3:74-78 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50384691 |
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| n/a |
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| Name | BDBM50384691 |
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| Synonyms: | CHEMBL2037125 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23F3N2O3 |
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| Mol. Mass. | 480.4783 |
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| SMILES | Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ccc(CCCO)cc12 |
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| Structure | 
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