Reaction Details |
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Target | Bile acid receptor |
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Ligand | BDBM50385201 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_822295 (CHEMBL2038598) |
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EC50 | 1300±n/a nM |
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Citation | Marinozzi, M; Carotti, A; Sansone, E; Macchiarulo, A; Rosatelli, E; Sardella, R; Natalini, B; Rizzo, G; Adorini, L; Passeri, D; De Franco, F; Pruzanski, M; Pellicciari, R Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists. Bioorg Med Chem20:3429-45 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bile acid receptor |
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Name: | Bile acid receptor |
Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
Type: | Nuclear Receptor |
Mol. Mass.: | 55916.24 |
Organism: | Homo sapiens (Human) |
Description: | Q96RI1 |
Residue: | 486 |
Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
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BDBM50385201 |
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n/a |
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Name | BDBM50385201 |
Synonyms: | CHEMBL2037334 |
Type | Small organic molecule |
Emp. Form. | C26H22IN3O2S |
Mol. Mass. | 567.441 |
SMILES | CC1SC(c2c(C)nn(c2NC1=O)-c1ccccc1I)c1ccc(Oc2ccccc2)cc1 |
Structure |
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