| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bile acid receptor |
|---|
| Ligand | BDBM50385210 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_822295 (CHEMBL2038598) |
|---|
| EC50 | 1900±n/a nM |
|---|
| Citation |  Marinozzi, M; Carotti, A; Sansone, E; Macchiarulo, A; Rosatelli, E; Sardella, R; Natalini, B; Rizzo, G; Adorini, L; Passeri, D; De Franco, F; Pruzanski, M; Pellicciari, R Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists. Bioorg Med Chem20:3429-45 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bile acid receptor |
|---|
| Name: | Bile acid receptor |
|---|
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
|---|
| Type: | Nuclear Receptor |
|---|
| Mol. Mass.: | 55916.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI1 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
|
|
|
|---|
| BDBM50385210 |
|---|
| n/a |
|---|
| Name | BDBM50385210 |
|---|
| Synonyms: | CHEMBL2037324 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27N3O3S |
|---|
| Mol. Mass. | 485.597 |
|---|
| SMILES | COc1cc(ccc1Oc1ccccc1)[C@H]1S[C@@H](C)C(=O)Nc2c1c(C)nn2-c1ccccc1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
