| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase FKBP4 |
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| Ligand | BDBM50388313 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_829711 (CHEMBL2061151) |
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| IC50 | >100000±n/a nM |
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| Citation |  Gopalakrishnan, R; Kozany, C; Gaali, S; Kress, C; Hoogeland, B; Bracher, A; Hausch, F Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. J Med Chem55:4114-22 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase FKBP4 |
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| Name: | Peptidyl-prolyl cis-trans isomerase FKBP4 |
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| Synonyms: | FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51793.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_154482 |
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| Residue: | 459 |
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| Sequence: | MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKD
KLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPN
AELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWL
EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRG
EAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAE
EENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
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| BDBM50388313 |
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| n/a |
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| Name | BDBM50388313 |
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| Synonyms: | TIMCODAR |
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| Type | Small organic molecule |
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| Emp. Form. | C43H45ClN4O6 |
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| Mol. Mass. | 749.294 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)C(=O)N(C)[C@@H](Cc1ccc(Cl)cc1)C(=O)N(Cc1ccccc1)C(CCc1ccncc1)CCc1ccncc1 |
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| Structure | 
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