Reaction Details |
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Target | Glycogen synthase kinase-3 alpha |
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Ligand | BDBM50389078 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_833721 (CHEMBL2066820) |
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IC50 | 54±n/a nM |
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Citation | Lo Monte, F; Kramer, T; Gu, J; Anumala, UR; Marinelli, L; La Pietra, V; Novellino, E; Franco, B; Demedts, D; Van Leuven, F; Fuertes, A; Dominguez, JM; Plotkin, B; Eldar-Finkelman, H; Schmidt, B Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3a. J Med Chem55:4407-24 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 alpha |
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Name: | Glycogen synthase kinase-3 alpha |
Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
Type: | Enzyme |
Mol. Mass.: | 50991.79 |
Organism: | Homo sapiens (Human) |
Description: | P49840 |
Residue: | 483 |
Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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BDBM50389078 |
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n/a |
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Name | BDBM50389078 |
Synonyms: | CHEMBL2064539 |
Type | Small organic molecule |
Emp. Form. | C26H21N3O4S |
Mol. Mass. | 471.528 |
SMILES | COC[C@H]1COc2ccc(cc2O1)-c1nnc(SCc2ccc(cc2)-c2ccccc2C#N)o1 |r| |
Structure |
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